主讲人简历：

Education

09/1993-12/1998

Ph. D., Polymer Chemistry and Physics, Jilin University, P. R. China

09/1996 –09/1997

Joint training Ph.D. student, University of Munich, Germany

09/1989-07/1993

B.S.,PolymerEngineering; Minor: TechnicalEconomy and Management, Tianjin University, P. R. China

Professional Experience

07/2013-present  

Professor, Department of Chemistry, University of British Columbia, Canada

10/2004-09/2014

Canada Research Chair (Tier II) in Molecular Nanoscience and Protein Engineering, Department of Chemistry, University of British Columbia, Canada

07/2009-06/2013

Associate Professor with tenure, Department of Chemistry, University of British Columbia, Canada

08/2004-06/2009

Assistant Professor, Department of Chemistry, University of British Columbia, Canada

08/2002-08/2004

Associate Research Scientist, Columbia University, New York, NY, USA.

01/1999-08/2002

Research Fellow, Mayo Medical Center, Rochester, MN, USA

Honors and Awards

2017Plenary Speaker, the 15th Pacific Polymer Congress
2016  Applied Chemsitry Lectureship, Changchun Institute of Applied Chemistry

2012  Changjiang Scholar Distinguished Professor, Jilin University
2011  JILA Distinguished Visiting Fellowship
2011  Alexander von Humboldt Foundation Research Fellowship

2011  Charles A. McDowell Award for Excellence in Research
2010-2013  NSERC Discovery Accelerator Supplement Award
2006-2012  Career Investigator Award, Michael Smith Foundation for Health Research

2004-2014  Canada Research Chair (Tier II) in Molecular Nanoscience and Protein Engineering

Research Interest

Protein mechanics and engineering at the single molecule level, Protein-based biomaterials Protein folding and unfolding dynamics

Selected Ppublication（since 2010）

1. Li, H. and Zheng, P. Curr. Opin Chem. Biol., 43, 58-67 (2018).

2. Lei, H., Guo, Y., Hu, X., Hu, C., Hu, X. and Li, H. B. J. Am. Chem. Soc. 139, 1358 (2017).

3. Lei, H., He, C., Hu, C., Li, J., Hu, X., Hu, X. and Li, H. Angew. Chem. Int. Ed., 56, 6117 (2017).

4. Lyu, S., Fang, J., Duan, T., Fu, L., Liu, J. and Li, H. Chem. Commun., 53, 13375 (2017).

5. Gao, X., Lyu, S. and Li, H. Biomacromolecules, 18, 3726-3732 (2017).

6. Gao, X., Fang, J., Xue, B., Fu, L. and Li, H. Biomacromolecules, 17, 2812−2819 (2016).
7. Zheng, P., Arantes, G. M., Field, M. J. and Li, H. B. Nature Commun., 6, 7569 (2015).

8. He, C., Hu, C., Hu, X., Hu, X., Xiao, A., Perkins, T.T. and Li, H. B. Angew. Chem. Intnl. Ed., 54, 9921 (2015).

9. Zheng, P., Wang, Y. and Li, H. Angew. Chem. Int. Ed. 53, 14060-14063 (2014).

10. Kong, N., Peng, Q. and Li, H., Adv. Funct. Mater. 24, 7310–7317 (2014).

11. He, C., Lamour, G., Xiao, A., Gsponer, J., Li, H. J. Am. Chem. Soc. 136, 11946−11955 (2014).

12. Fang, J., Mehlich, A., Koga, N., Huang, J., Koga, R., Gao, X., Hu, C., Jin, C., Rief, M., Kast, J.,Baker, D., Li, H. Nature Commun., 4, 2974 (2013).

13. Zoldak, G. ; Stigler, J. ; Pelz, B. ; Li, H. ; Rief, M. Proc. Natl. Acad. Sci. USA., 110, 18156-18161 (2013).

14. Zheng, P., Takayama, S.J., Mauk, A.G. and Li, H. B. J. Am. Chem. Soc., 134, 4124-4131(2012).

15. Zheng, P. and Li, H., J. Am. Chem. Soc. 133, 6791-6798 (2011).

16. Aioanei, D., Lv, S., Tessari, I., Rampioni, A. Bubacco, L., Li, H. Samori, B. and Brucale, M.,

Angew. Chem. Int. Ed. Engl. 50, 4394-4397 (2011).

17. Lv, S., Dudek, D.M., Cao, Y., Balamurali, M.M., Gosline, J. & Li, H. Nature, 465, 69-73 (2010)

18. Li, H. and Cao, Y., Acc. Chem. Res. 43, 1331-1341 (2010).

讲座介绍：

Elastomeric proteins function as molecular springs in their biological settings to establish elastic connections, and provide mechanical strength, elasticity and extensibility. To fulfill their biological functions, elastomeric proteins have evolved to assume different structures, from simple random coil-like structure to more sophisticated beads-on-a-string conformation, and exhibit distinct mechanical properties.The development of single molecule force spectroscopy techniques has made it possible to directly probe the mechanical properties of such elastomeric proteins at the single molecule level and allowed to understand molecular design principles of these complex protein polymers. This knowledge has enabled us to engineer novel elastomeric proteins to achieve tailored and well-defined nanomechanical properties. Going a step further, we have started to employ these novel elastomeric proteins as building blocks to construct protein-based biomaterials, which in turn provide an ideal system to understand how single molecule nanomechanical features are translated into biomechanical properties of macroscopic materials. These studies will pave the way to utilizing proteins as building blocks to engineer new generations of protein-based biomaterials for diverse applications in biomedical engineering as well as material sciences.